Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner

Age effects on the regulation of adult h

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

✍ Sebastian Mirochnic; Susanne Wolf; Matthias Staufenbiel; Gerd Kempermann 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 568 KB

## Abstract An active lifestyle is to some degree protective against Alzheimer's disease (AD), but the biological basis for this benefit is still far from clear. We hypothesize that physical and cognitive activity increase a reserve for plasticity by increasing adult neurogenesis in the hippocampal