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Phylogeny and evolutionary rates of G protein α subunit genes

✍ Scribed by Shozo Yokoyama; William T. Starmer

Publisher
Springer
Year
1992
Tongue
English
Weight
933 KB
Volume
35
Category
Article
ISSN
0022-2844

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✦ Synopsis

Rooted phylogenetic trees for a total of 34 genes encoding the stimulatory (s alpha), inhibitory (i alpha), transducin (t alpha), Gx (x alpha), Gz (z alpha), G11 (alpha 11), G12 (alpha 12), G13 (alpha 13), G16 (alpha 16), Gq (q alpha), and other (o alpha) G protein alpha subunits have been constructed. The analysis shows that the G12 (alpha 12 and alpha 13), Gq (alpha 11, alpha 16, and q alpha), and Gs (s alpha genes) groups form one cluster, and the Gx (x alpha and z alpha genes), G(i) (i alpha genes), Gt (t alpha 1 and t alpha 2), and G(o) (o alpha genes) groups form another cluster. During mammalian evolution, the rates of synonymous substitutions for these genes were estimated to be between 1.77 x 10(-9)/site/year and 5.63 x 10(-9)/site/year, whereas those of non-synonymous substitutions were between 0.008 x 10(-9)/site/year and 0.067 x 10(-9)/site/year. These evolutionary rates are similar to those for histone genes, suggesting equally important biological functions of the G protein alpha subunits.

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