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Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes

✍ Scribed by J. C. Igual; C. González-Bosch; J. Dopazo; J. E. Pérez-Ortín

Publisher
Springer
Year
1992
Tongue
English
Weight
894 KB
Volume
35
Category
Article
ISSN
0022-2844

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✦ Synopsis

The thiolase family is a widespread group of proteins present in prokaryotes and three cellular compartments ofeukaryotes. This fact makes this family interesting in order to study the evolutionary process of eukaryotes. Using the sequence ofperoxisomal thiolase from Saccharomyces cerevisiae recently obtained by us and the other known thiolase sequences, a phylogenetic analysis has been carried out. It shows that all these proteins derived from a primitive enzyme, present in the common ancestor ofeubacteria and eukaryotes, which evolved into different specialized thiolases confined to various cell compartments. The evolutionary tree obtained is compatible with the endosymbiotic theory for the origin of peroxisomes.

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