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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

✍ Scribed by Barbara J. Ring; Jenny Y. Chien; Kimberly K. Adkison; Hannah M. Jones; Malcolm Rowland; Rhys Do Jones; James W. T. Yates; M. Sherry Ku; Christopher R. Gibson; Handan He; Ragini Vuppugalla; Punit Marathe; Volker Fischer; Sandeep Dutta; Vikash K. Sinha; Thorir Björnsson; Thierry Lavé; Patrick Poulin


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
409 KB
Volume
100
Category
Article
ISSN
0022-3549

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The empirical and physiological predictive approaches to human clearance were evaluated using preclinical in vitro and in vivo data of various datasets to establish a methodology for the prediction of clearance. Among the examined empirical approaches, an allometric scaling method with the rule of e