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Phrenic nerve transfer in the treatment of brachial plexus avulsion: An experimental study of nerve regeneration and muscle morphology in rats

✍ Scribed by Cheng-Gang Zhang; Jian-Jun Ma; Giorgio Terenghi; Cristina Mantovani; Mikael Wiberg

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
504 KB
Volume
24
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

The regeneration of motor and sensory neurons and the morphological changes of the target muscle after phrenic nerve transfer were investigated in adult rats. Six months following nerve transfer, 326.0 ± 16.31 phrenic motoneurons regenerated into musculocutaneous nerve, which is not different from the normal number of phrenic motoneurons. The regenerated motoneurons exhibited a 14% nonsignificant hypertrophy. Of the dorsal root ganglia (DRG) neurons, 255.8 ± 45.26 regenerated, which was significantly lower than the number of normal phrenic DRG neurons. The regenerated phrenic DRG neurons showed a 24% close‐to‐significant atrophy. The target muscle fiber morphology changed considerably after reinnervation. The present results suggest that the phrenic nerve has very good regenerative ability in terms of its motoneurons and a relatively insufficient sensory neuronal regeneration. © 2004 Wiley‐Liss, Inc.

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