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Phototoxicity of benzo[a]pyrene by ultraviolet A irradiation: induction of apoptosis in Jurkat cells

✍ Scribed by Yuko Ibuki; Rensuke Goto

Book ID
117766108
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
420 KB
Volume
11
Category
Article
ISSN
1382-6689

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## Abstract The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl‐inositol‐3 (PI‐3) kinases su