Photothermal response of superparamagnetic iron oxide nanoparticles

✍ Scribed by Jihoon Kim; Junghwan Oh; Hyun Wook Kang; Marc D. Feldman; Thomas E. Milner

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 125 KB
• Volume: 40
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.20650

✦ Synopsis

Abstract

Background and Objective

Superparamagnetic iron oxide nanoparticles have been used as MRI contrast agents in medical imaging. The purpose of this study was to explore the photothermal response of superparamagnetic iron oxide nanoparticles for biomedical applications.

Study Design/Materials and Methods

Absorbance, temperature increase, and optical path length change of solutions of superparamagnetic iron oxide nanoparticles, SPIO and MION, in response to a 532 nm pulsed laser irradiation were measured.

Results

Both SPIO and MION showed absorption at 532 nm, temperature increase, and optical path length change. SPIO and MION underwent selective heating due to absorption of laser energy (532 nm).

Conclusion

Temperature increase and optical path length change of SPIO and MION in response to 532 nm pulsed laser irradiation demonstrate a potential application of these particles in biomedical imaging. For further study, additional experiments applying the photothermal response of SPIO and MION in tissues are required. Lesers Surg. Med. 40:415–421, 2008. © 2008 Wiley‐Liss, Inc.