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Photosensitization with methylene-linked porphyrin dimers

✍ Scribed by David Kessel; C.K. Chang; Barbara W. Henderson

Book ID
103994377
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
408 KB
Volume
18
Category
Article
ISSN
1011-1344

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✦ Synopsis

The photodynamic therapy (PDT) efficacy of a series of porphyrin dimers linked by methylene groups was evaluated using the radiation-induced fibrosarcoma (RIF) tumor model. Longer chain length led to greater efficacy and increased dimer hydrophobicity. This result was correlated with the persistence of porphyrins in plasma, but not with tissue levels.

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