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Photomodulation of the Redox and Folding Adjuvant Properties of Bis(cysteinyl) Peptides

✍ Scribed by Chiara Cabrele; Anna Cattani-Scholz; Christian Renner; Raymond Behrendt; Dieter Oesterhelt; Luis Moroder


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
244 KB
Volume
2002
Category
Article
ISSN
1434-193X

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Melarsen oxide [p-(4,6-diamino-1,3,5-triazin-2-yl)aminophenylarsonous acid (MEL)], which selectively bridges spatially neighboring bis-cysteinyl residues in (reduced) proteins, was used to trap folding intermediates chemically during 1) time-dependent renaturation of recombinant human macrophage col