𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Photodynamic therapy with m-tetrahydroxyphenylchlorin in vivo: Optimization of the therapeutic index

✍ Scribed by Hans-Beat Ris; Hans J. Altermatt; Charles M Stewart; Thomas Schaffner; Qiang Wang; Chang K. Lim; Raymond Bonnett; Ulrich Althaus

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
660 KB
Volume
55
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

The therapeutic index of meta-tetrahydroxyphenylchlorinmediated photodynamic therapy (mTHPC-PDT) was assessed in BALB/c nude mice bearing human malignant mesothelioma xenografts. Equal doses of 650 nm laser light were delivered to the tumour and to an equal-sized area of the hind leg (control site) after i.p. administration of mTHPC. Twenty-one groups of 6 animals each were treated under various drug-light conditions and at drug-light intervals ranging from 4 hr to 6 days. After light delivery the extent of tumour necrosis and the depth of alterations in normal tissue were assessed by light microscopy of standardized histological sections. A therapeutic index (TI) of mTHPC-PDT was defined as the cross-sectional area of tumour necrosis per depth of visible tissue injury at the control site. This TI was strongly related to the conditions of treatment. In particular, it was increased by prolonging the drug-light interval up to 5 days and by increasing the dose of light for any dose of drug. The most profound increase of TI was obtained by increasing the intensity of light administered at the chosen interval while reducing the dose of drug. Our findings suggest that threshold conditions operate in PDT and have important implications for clinical application of the treatment.

πŸ“œ SIMILAR VOLUMES

Photodynamic therapy (PDT) of the ciliar
Photodynamic therapy (PDT) of the ciliary body with silicon naphthalocyanine (SINc) in rabbits
✍ Hill, R.A.; Garrett, J.; Reddi, S.; Esterowitz, T.; Liaw, L.-H.; Ryan, J.; Shirk πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 603 KB

## Background and Objective: To investigate silicone naphthalocyanine (SINc; 0.5 mgkg) for photodynamic therapy (PDT) of the ciliary body in pigmented rabbits. Study DesignlMateriaZs and Methods: SINc was dissolved in canola oil by heating, emulsified with Tween-SO, and given by ear vein. Pharmaco

Mechanism of cell death mediated by a BF
Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: Dissection of the apoptotic pathway in vitro and in vivo
✍ Aisling E. O'Connor; Margaret M. Mc Gee; Yury Likar; Vladimir Ponomarev; John J. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 French βš– 822 KB

## Abstract Photodynamic therapy (PDT) is an established treatment modality for cancer. ADPM06 is an emerging non‐porphyrin PDT agent which has been specifically designed for therapeutic application. Recently, we have demonstrated that ADPM06‐PDT is well tolerated __in vivo__ and elicits impressive

Inhibition of the Akt, cyclooxygenase-2,
Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer
✍ Hiroshi Miyamoto; Saleh Altuwaijri; Yi Cai; Edward M. Messing; Chawnshang Chang πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 111 KB

## Abstract Prostate cancer cells are generally dependent on androgen stimulation mediated by the androgen receptor (AR) for growth and survival, and, therefore, hormonal manipulation, such as castration and/or the use of AR antagonists, results in a regression of the cancer. However, this treatmen