✦ LIBER ✦

Photodynamic therapy for rat pituitary tumor in vitro and in vivo using pheophorbide-a and white light

✍ Scribed by Takashi Yano; Tohru Uozumi; Keiichi Kawamoto; Kazutoshi Mukada; Jun Onda; Akihiro Ito; Nariaki Fujimoto

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 1008 KB
Volume: 11
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.1900110212

No coin nor oath required. For personal study only.

✦ Synopsis

This is the first report on the use of photodynamic therapy (PDT) for rat pituitary tumor in vivo. Rat pituitary tumor (GH,) cells were cultured, GH, tumor was subcutaneously implanted in nude mice, and pheophorbide-a (Ph-a) and white light were prepared. Photocytotoxicity proportional to Ph-a concentration, intensity of irradiation, and incubation time was observed in vitro. Despite the delay in the disappearance of Ph-a from the tumor, Ph-a in the pituitary gland rapidly decreased after intravenous administration in vivo. Through PDT, the tumor grossly disappeared, the plasma levels of rat growth hormone secreted from the tumor also remarkably decreased, and the development of giantism was inhibited. These results indicate that PDT is effective against rat pituitary tumor.

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