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Photodynamic inactivation of bacteria using polyethylenimine–chlorin(e6) conjugates: Effect of polymer molecular weight, substitution ratio of chlorin(e6) and pH

✍ Scribed by Liyi Huang; Timur Zhiyentayev; Yi Xuan; Dulat Azhibek; Gitika B. Kharkwal; Michael R. Hamblin

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 798 KB
Volume: 43
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.21056

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Chlorin e6 ( Ce 6) was conjugated with anti-tumor monoclonal antibody ( IgG 2 b ) to increase its binding affinity for tumors. The Ce 6 was activated by N -hydroxysuccinimide and directly conjugated with IgG 2 b ( IgG 2 b – Ce 6) via peptide bonds. An average of 11 Ce 6 molecules were coupled to eac