## Abstract ## Background and Objective Limited knowledge of the light and temperature distribution within the target volume in combination with nonโselective accumulation of the applied photosensitizers (PS) has hampered the clinical relevance of interstitial photodynamic therapy (iPDT) for treat
Photodynamic Efficiency of Protoporphyrin IX: Comparison of Endogenous Protoporphyrin IX Induced by 5-Aminolevulinic Acid and Exogenous Porphyrin IX
โ Scribed by Kenji Tabata; Shun-ichiro Ogura; Ichiro Okura
- Book ID
- 111412215
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 373 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0031-8655
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Protoporphyrin IX (Pp IX) is the main photosensitizer in photochemotherapy with 5-aminolevulinic acid (ALA). Pp IX is photolabile and the present work shows that 70-95% of Pp IX in cells is degraded by clinically relevant light exposures (40-200 J cm 22 at 630 nm). During light exposure a small yiel
The bioconversion of 5-aminolevulinic acid (ALA) into hydrophobic protoporphyrin IX and other water-soluble porphyrins was investigated in Ehrlich ascite carcinoma (EAC) cells and in a myeloma cell line. The effects of irradiation (514 nm), temperature, incubation time and added glucose on the relat
## Abstract ## BACKGROUND The aim of the current clinical study was to evaluate the in vivo fluorescence detection of ovarian carcinoma metastases in a secondโlook laparoscopic procedure after intraperitoneally applied 5โaminolevulinic acid (ALA). ## METHODS Five hours before laparoscopic surger