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Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate

✍ Scribed by Ana Fernandez Gacio; Carlos Fernandez-Marcos; Narasimha Swamy; Darra Dunn; Rahul Ray

Book ID
102304522
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
151 KB
Volume
99
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

We hypothesized that estrogen receptor (ER) in hormone‐sensitive breast cancer cells could be targeted for selective photodynamic killing of tumor cell with antiestrogen‐porphyrin conjugates by combining the over‐expression of ER in hormone‐sensitive breast cancer cells and tumor‐retention property of porphyrin photosensitizers. In this study we describe that a tamoxifen (TAM)‐pyropheophorbide conjugate that specifically binds to ERα, caused selective cell‐kill in MCF‐7 breast cancer cells upon light exposure. Therefore, it is a potential candidate for ER‐targeted photodynamic therapy of cancers (PDT) of tissues and organs that respond to estrogens/antiestrogens. J. Cell. Biochem. 99: 665–670, 2006. © 2006 Wiley‐Liss, Inc.

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✍ Narasimha Swamy; Ajay Purohit; Ana Fernandez-Gacio; Graham B. Jones; Rahul Ray 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

## Abstract We hypothesized that over‐expression of estrogen receptor (ER) in hormone‐sensitive breast cancer could be harnessed synergistically with the tumor‐migrating effect of porphyrins to selectively deliver estrogen‐porphyrin conjugates into breast tumor cells, and preferentially kill the tu