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Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL

✍ Scribed by Sabine Kneissl; E. Joel Loveridge; Christopher Williams; Matthew P. Crump; Rudolf K. Allemann


Book ID
102790014
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
771 KB
Volume
9
Category
Article
ISSN
1439-4227

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✍ Verónica Ayllón; Xavier Cayla; Alphonse García; Aarne Fleischer; Angelita Reboll 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB

Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates. Serine phosphorylation of Bcl-xL and Bcl-w correlates with the number of trimolecular complexes formed. Depletion of Bcl-xL and Bcl