A novel solid support for derivatization
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Petri Heinonen; Harri LΓΆnnberg
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Article
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1997
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Elsevier Science
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French
β 215 KB
A hydroxymethylated polystyrene resin has been convened to its vinyisuifonylethyl ether (1) by DBU catalyzed addition of the hydmxy groups to divinyl sulfone. The support obtained was used to convert 5-and 6-(tetrahydropyran-2-yloxy)-1,2,3,4-tetrahydroisoquinolines to a set of N-alkylated tetrahydro