Photochemical and radiochemical alkylation of caffeine by alkyl amines

✍ Scribed by A. Stankunas; I. Rosenthal; J.N. Pitts Jr.

• Book ID: 104248480
• Publisher: Elsevier Science
• Year: 1971
• Tongue: French
• Weight: 156 KB
• Volume: 12
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)97613-0

✦ Synopsis

Photochemical and radiochemical reactions of purines may serve as model systems of radiation damage to DNA in living organisms. Elad and co-workers (1) have shown that reactions involving alkylation of the purine bases in nucleic acids are closely paralleled by reactions of caffeine. Although purines are relatively stable compared to pyrimidines in interaction with U. V. light (Z), several reactions are reported concerning them. Linschitr. and Conolly (3) reported the photochemical addition of alcohols to the 5, b double bond of purine. Elad and co-workers (4) have reported the substitution at the 8-position of a number of purines by alcohols. Jerumanis and Martel observed the photoseneitized reaction of