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Photocaged DNA Provides New Levels of Transcription Control

✍ Scribed by Luke M. Ceo; Prof. John T. Koh

Book ID
101820545
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
246 KB
Volume
13
Category
Article
ISSN
1439-4227

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✦ Synopsis

Spot lit: photocaged nucleic acids have been used to regulate gene expression through the action of light. Whereas most methods target mRNAs, DNA decoys have recently been used to target DNA transcription by targeting specific DNA-transcription-factor interactions. This has allowed researchers to "turn-off" transcription through the action of light on caged nucleic acids for the first time.

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## Abstract Carboxy‐terminal binding protein (CtBP) is a well‐known corepressor of several DNA binding transcription factors in __Drosophila__ as well as in mammals. CtBP is implicated in Polycomb Group (PcG) complex‐mediated transcriptional repression because it can bind to some PcG proteins, and