## Abstract Photochemical activation is a very attractive way to achieve precise spatial and temporal control of the biological action of transition‐metal complexes that behave as inactive “prodrugs” in the dark. A significant amount of work has been devoted to metal complexes that act on DNA. In t
Photoactivated Biological Activity of Transition-Metal Complexes (Eur. J. Inorg. Chem. 10/2010)
✍ Scribed by Ulrich Schatzschneider
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 997 KB
- Volume
- 2010
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
Abstract
The cover picture shows examples of metal complexes with photoactivated biological activity, as symbolized by the lightning in the background. This includes liberation of small‐molecule messengers, such as carbon monoxide, nitric oxide, and neuroactive amines from the metal coordination sphere, as well as light‐triggered oxidative or covalent modification of DNA. More examples are presented in the Microreview by U. Schatzschneider on p. 1451 ff.
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## Abstract **The cover picture shows** the constellation scorpio (lat. scorpius), which symbolises the heteroscorpionate ligands described in the article. To the left, a complex bearing such a heteroscorpionate ligand is fixed on a solid phase. In the back, another ligand with a linker for immobil