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Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56 lck SH2 Domain

✍ Scribed by Llinàs-Brunet, Montse; Beaulieu, Pierre L.; Cameron, Dale R.; Ferland, Jean-Marie; Gauthier, Jean; Ghiro, Elise; Gillard, James; Gorys, Vida; Poirier, Martin; Rancourt, Jean; Wernic, Dominik; Betageri, Raj; Cardozo, Mario; Jakes, Scott; Lukas, Suzanne; Patel, Usha; Proudfoot, John; Moss, Neil


Book ID
126804289
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
141 KB
Volume
42
Category
Article
ISSN
0022-2623

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## Abstract Spleen tyrosine kinase (Syk) plays an essential role in IgE receptor signaling (FcεRI), which leads to mast cell degranulation. Divalent binding of the tandem SH2 domain (tSH2) of Syk to the intracellular ITAM motif of FcεRI activates the kinase domain of Syk, and thereby initiates cell