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Phosphotriester approach to oligothymidylate synthesis utilizing a simple thymidine unit and a new type of condensing agents

✍ Scribed by Mitsuo Sekine; Jun-ichi Matsuzaki; Tsujiaki Hata


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
247 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis


DMTrTp(SPh)2 was proposed as a simplest "nucleotide unit" for the synthesis of olygothymidylates.

Onephenylthio group was removed selectivelyandrapidly from dithiol-estersby1M pyridinium hypophosphonate. Two kinds of arenedisulfonyl chlorides were newly preparedandutilized as promising condensing agents.