Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs

Alteration of G1 cell-cycle protein expr

Alteration of G1 cell-cycle protein expression and induction of p53 but not p21/waf1 by the DNA-modifying carcinogen 2-acetylaminofluorene in growth-stimulated hepatocytes in vitro

✍ Birgitte Lindeman; Ellen Skarpen; G. Hege Thoresen; Thoralf Christoffersen; Lene 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 282 KB 👁 1 views

2-Acetylaminofluorene (AAF) is a potent tumor promoter in rat liver carcinogenesis models. In the resistant hepatocyte model, AAF is combined with a growth stimulus for efficient promotion of preneoplastic lesions. The promoting property of AAF in this model is closely associated with mito-inhibitio