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Phosphorylation of tubulin tyrosine ligase: A Potential Mechanism for Regulation of ?-Tubulin Tyrosination

โœ Scribed by Idriss, Haitham T.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
77 KB
Volume
46
Category
Article
ISSN
0886-1544

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โœฆ Synopsis

The tubulin tyrosination/detyrosination cycle is a well-established posttranslational modification, which is carried out by two enzymes: Tubulin Tyrosine Ligase (TTL) and Tubulin Tyrosine Carboxypeptidase (TTCP). In this paper, I present evidence suggesting that the cycle itself is under the hierarchical control of reversible phosphorylation and that PKC mediated phosphorylation of TTL inhibits its activity, thereby preventing tubulin tyrosination. Phosphorylation of TTL is predicted to occur in a postulated Mg ฯฉฯฉ /-ATP binding fold, leading to inhibition of Mg ฯฉฯฉ /ATP binding and TTL mediated catalysis. The implications of such control are also discussed.

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