✦ LIBER ✦

Phosphorylation of proteins in neuron terminals: Specificity depends on coincidental signaling

✍ Scribed by Lixing Zhang; Sylvette Tinette; Alain Robichon

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 255 KB
Volume: 88
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10363

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✦ Synopsis

Abstract

We investigate the role of neuronal coincidental signaling mediated by the second messengers, on phosphorylation of three major proteins of neurosecretory vesicles. Our data show that different combinations of coincidental signaling generate specific pattern of phosphoproteins and not strictly additional effects. This suggests that an added phosphate on a site might ‘mask’ or ‘unmask’ the next sites for specific kinases and phosphatases action by inducing conformation change or protein association. We show that a function of vesicles such as the uptake of glutamate is highly regulated by coincidental signaling. © 2002 Wiley‐Liss, Inc.

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