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Phosphorylation of hepatocyte growth factor receptor and epidermal growth factor receptor of human hepatocytes can be maintained in a (3D) collagen sandwich culture system

✍ Scribed by Tobias Engl; Kim A. Boost; Kerstin Leckel; Wolf-Dietrich Beecken; Dietger Jonas; Elsie Oppermann; Marcus K.H. Auth; André Schaudt; Wolf-Otto Bechstein; Roman A. Blaheta


Book ID
116919165
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
298 KB
Volume
18
Category
Article
ISSN
0887-2333

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The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat