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Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase

✍ Scribed by Chaoyong Zhu; Magnus Johansson; Johan Permert; Anna Karlsson


Book ID
113994134
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
359 KB
Volume
56
Category
Article
ISSN
0006-2952

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We have examined analogs of the previously reported 7-deaza-2Ј-deoxypurine nucleoside triphosphate series of human telomerase inhibitors. Two new telomerase-inhibiting nucleotides are reported: 6-methoxy-7-deaza-2Ј-deoxyguanosine 5Ј-triphosphate (OMDG-TP) and 6-thio-7-deaza-2Ј-deoxyguanosine 5Ј-trip