The present investigation provides the first indication that constitutive, calcium-independent phospholipase A 2 activity (iPLA 2 ) modulates phosphorylation of the ␣-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of glutamate receptors. Preincubation of frozenthawed brain sections wi
✦ LIBER ✦
Phosphorylation of AMPA receptor subunits is differentially regulated by phospholipase A2 inhibitors
✍ Scribed by Caroline Ménard; Christian Patenaude; Guy Massicotte
- Book ID
- 116767996
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 246 KB
- Volume
- 389
- Category
- Article
- ISSN
- 0304-3940
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## Abstract The calcium‐independent form of phospholipase A2 (iPLA2), an enzyme known to generate arachidonic acid (AA), was recently identified as the predominant constitutive phospholipase in the hippocampus. The present study shows that the iPLA2 inhibitor bromoenol lactone, when introduced into