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Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C

✍ Scribed by Eric Duplus; Christelle Gras; Vanessa Soubeyre; Guilan Vodjdani; Yolande Lemaigre-Dubreuil; Bernard Brugg


Book ID
111180597
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
477 KB
Volume
104
Category
Article
ISSN
0022-3042

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The heat-stable enterotoxin STa of E. coli causes diarrhea by binding to and stimulating intestinal membrane-bound guanylyl cyclase, triggering production of cyclic GMP. Agents which stimulate protein kinase C (PKC), including phorbol esters, synergistically enhance STa effects on cGMP and secretion