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Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes

✍ Scribed by Guimei Wu; José Marín-García; Terry B. Rogers; Edward G. Lakatta; Xilin Long


Book ID
119212159
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
303 KB
Volume
10
Category
Article
ISSN
1532-8414

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The gene expression of heme oxygenase-1 (HO-1) was studied in mammalian cell lines exposed to hyperoxia. Northern blot analysis demonstrated that hyperoxic exposure increased the HO-1 mRNA levels in various types of cells, including human hepatoma (HepG2) cells. This increase was time-and dose-depen