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Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint

✍ Scribed by Chen, Rey-Huei

Book ID
110030701
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
324 KB
Volume
23
Category
Article
ISSN
0261-4189

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To determine sequence variations of the BUB1 and BUB1B genes in pancreatic cancer, the entire coding regions of the BUB1 and BUB1B genes were sequenced in pancreatic cancer cell lines and xenografts. Although only polymorphic alterations were found in the BUB1B gene, the aneuploid pancreatic cell li