Geldanamycin, an hsp90/GRP94-binding dru
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Beth Lawson; Joseph W. Brewer; Linda M. Hendershot
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Article
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1998
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John Wiley and Sons
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English
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Geldanamycin, a benzoquinone ansamycin, binds specifically to hsp90 and GRP94 in vitro and in vivo. Treatment of cells with geldanamycin alters the molecular chaperone function of hsp90, and as a result, blocks certain cytosolic proteins from reaching their mature form, inhibits their activity, and/