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Phosphorylated PKR contributes the induction of GRP94 under ER stress

โœ Scribed by Mototsugu Ito; Reiko Onuki; Yoshio Bando; Masaya Tohyama; Yuichi Sugiyama


Book ID
116295234
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
219 KB
Volume
360
Category
Article
ISSN
0006-291X

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Geldanamycin, a benzoquinone ansamycin, binds specifically to hsp90 and GRP94 in vitro and in vivo. Treatment of cells with geldanamycin alters the molecular chaperone function of hsp90, and as a result, blocks certain cytosolic proteins from reaching their mature form, inhibits their activity, and/