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Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab

✍ Scribed by Mario Scartozzi, Riccardo Giampieri, Elena Maccaroni, Alessandra Mandolesi, Simona Biagetti, Simona Alfonsi, Lucio Giustini, Cristian Loretelli, Luca Faloppi, Alessandro Bittoni, Maristella Bianconi, Michela Del Prete, Italo Bearzi, Stefano Cascinu


Book ID
119905316
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
297 KB
Volume
10
Category
Article
ISSN
1479-5876

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✍ Mario Scartozzi; Alessandra Mandolesi; Riccardo Giampieri; Chiara Pierantoni; Fo πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 245 KB

## Abstract Seventy to 40% of K‐RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti‐EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF‐1 system, altered activation colorectal cancer cells may escape anti‐EGF