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Phosphoryl-transfer reactions of phosphodiesters: characterization of transition states by heavy-atom isotope effects

โœ Scribed by Hengge, Alvan C.; Cleland, W. W.


Book ID
118156413
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
998 KB
Volume
113
Category
Article
ISSN
0002-7863

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## Abstract The nucleotides of DNA and RNA are joined by phosphodiester linkages whose synthesis and hydrolysis are catalyzed by numerous essential enzymes. Two prominent mechanisms have been proposed for RNA and protein enzyme catalyzed cleavage of phosphodiester bonds in RNA: (a) __intra__molecul