Phosphoric Acid-Catalyzed Enantioselective Transfer Hydrogenation of N-Aryl-ortho-Hydroxybenzophenone Ketimines

✍ Scribed by Thanh Binh Nguyen; Hadjira Bousserouel; Qian Wang; Françoise Guéritte

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 169 KB
• Volume: 353
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000754

✦ Synopsis

Abstract

The first enantioselective chiral phosphoric acid‐catalyzed transfer hydrogenation of N‐aryl‐ortho‐hydroxybenzophenone ketimines using a Hantzsch ester as hydrogen source was developed to afford, after removal of the N‐aryl group, the corresponding chiral diarylmethylamines in high yields and enantioselectivities.