๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

PHOSPHOLIPIDS AND NUCLEAR RNA

โœ Scribed by E. ALBI; M. MICHELI; M.P. VIOLA MAGNI

Book ID
102565685
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
300 KB
Volume
20
Category
Article
ISSN
1065-6995

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โœฆ Synopsis

Abstract

It has been demonstrated that in hepatocyte nuclei the chromatin phospholipid fraction is localized near the RNA in decondensed chromatin. The aim of the present study was to see if there is any linkage between phospholipids and other nuclear components. Isolated hepatocyte nuclei and nuclear membranes were treated with deoxyribonuclease and ribonuclease. No loss of phospholipids was observed after DNA digestion, whereas 48% was lost following enzymatic RNA removal. This loss of phospholipids, localized either near the membrane or inside the nucleus, was not homogeneous for all phospholipids: phosphatidylserine and sphingomyelin being the most affected. It can be concluded that 48% of nuclear phospholipids, in particular sphingomyelin, is lost with RNA removal. This result is discussed in view of a possible role of phospholipids in DNA synthesis and RNA transcription.

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