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Phospholipase-like myotoxins induce Ca2+ increase in muscle cells in culture

✍ Scribed by S. Rufini; S. Incerpi; J.Z. Pedersen

Book ID
116074818
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
95 KB
Volume
33
Category
Article
ISSN
0041-0101

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## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamate‐induced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe