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Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

✍ Scribed by Bivona, Trever G.; Pérez de Castro, Ignacio; Ahearn, Ian M.; Grana, Theresa M.; Chiu, Vi K.; Lockyer, Peter J.; Cullen, Peter J.; Pellicer, Angel; Cox, Adrienne D.; Philips, Mark R.


Book ID
109891237
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
666 KB
Volume
424
Category
Article
ISSN
0028-0836

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## Abstract Phospholipase C‐γ1 (PLCγ1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5‐inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCγ1 in PLCγ1‐mediated cell signaling, we character