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Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer

✍ Scribed by Xiaoliang Wang, Chongzhi Zhou, Guoqiang Qiu, Yinxue Yang, Dongwang Yan, Tonghai Xing, Junwei Fan, Huamei Tang, Zhihai Peng


Book ID
113093744
Publisher
Springer US
Year
2011
Tongue
English
Weight
567 KB
Volume
29
Category
Article
ISSN
1357-0560

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## Abstract The DNA‐damaging drug doxorubicin (Dox) induces cell senescence at concentrations significantly lower than those required for induction of apoptosis. At low Dox concentrations, tumor suppressor p53 is activated, which enhances the expression of p21^Waf1/Cip1^ (p21). At high concentratio