## Abstract Phospholipase C (PLC) activity and its response to stimulation by bile acids was assayed in cellular extracts from 16 primary human colon tumors of various Dukeβ²s stages and paired adjacent normal mucosal samples. In the absence of bile acid, there was negligible degradation of phosphat
Phospholipase activity in human bile
β Scribed by Toru Nakano; Jiro Yanagisawa; Fumio Nakayama
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 598 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0270-9139
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β¦ Synopsis
To investigate the importance of bacterial infection in the formation of free fatty acids found in brown pigment gallstones, free fatty acids and phospholipase activity in hepatic bile, with or without the presence of bacterial infection, were compared. The concentration of free fatty acids in bile with bacterial infection [0.467 f 0.447 mg per ml (mean f S.D.)] was significantly higher than when bacterial infection was absent (0.073 f 0.041 mg per ml; p < 0.01). However, there was no significant
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## Abstract Human preimplantation embryos secrete plateletβactivating factor (PAF), which stimulates prostaglandin E~2~ synthesis from secretory endometrium. This study investigated the action of PAF on phosphatidylinositol 4,5βbisphosphate (Ptdlns(4,5)P~2~)βspecific phospholipase C activity in hum