Phosphoinositide-specific phospholipase C in oat roots: association with the actin cytoskeleton

Ligands of CD4 inhibit the association o

Ligands of CD4 inhibit the association of phospholipase Cγ1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity

✍ Sébastien Jauliac; Fabienne Mazerolles; Nada Jabado; Annaïck Pallier; Frédéric B 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

We have previously shown that CD4 ligands inhibit interleukin-2 (IL-2) production and T cell proliferation in human peripheral CD4 + T lymphocytes, in an MHC-independent way. Two major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to the CD4 molecule, i. e. Ca 2+ s