Phosphoinositide 3-kinase γ has Multiple Phospholipid Binding Sites

Pim kinases phosphorylate multiple sites

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

✍ Andrew Macdonald; David G Campbell; Rachel Toth; Hilary McLauchlan; C James Hast 📂 Article 📅 2006 🏛 BioMed Central 🌐 English ⚖ 877 KB

## Background Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers. ## Results Here we sho