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Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF- B in Endothelial Cells

✍ Scribed by Li, X.; Tupper, J. C.; Bannerman, D. D.; Winn, R. K.; Rhodes, C. J.; Harlan, J. M.


Book ID
126093619
Publisher
American Society for Microbiology
Year
2003
Tongue
English
Weight
909 KB
Volume
71
Category
Article
ISSN
0019-9567

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Inhibition of phosphoinositide 3-kinase
✍ Ezra Aksoy; Wim Vanden Berghe; Sophie Detienne; Zoulikha Amraoui; Kathrine A. Fi πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 338 KB

Phosphoinositide 3-kinases (PI3K) are known to regulate Toll-like receptor (TLR)-mediated inflammatory responses, but their impact on the different pathways of TLR signaling remains to be clarified. Here, we investigated the consequences of pharmacological inhibition of PI3K on Toll-IL-1 receptor do