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Phosphoenolpyruvate in rat pancreatic islets: A possible intracellular trigger of insulin release?

✍ Scribed by M. C. Sugden; S. J. H. Ashcroft


Publisher
Springer
Year
1977
Tongue
English
Weight
580 KB
Volume
13
Category
Article
ISSN
0012-186X

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The contribution of drug metabolites to cyproheptadine (CPH)induced alterations in endocrine pancreatic B-cells was investigated by examining the inhibitory activity of CPH and its biotransformation products, desmethylcyproheptadine (DMCPH), CPH-epoxide and DMCPH-epoxide, on hormone biosynthesis and