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Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat

✍ Scribed by Elena Puerta; Isabel Hervias; Beatriz Goñi-Allo; Berta Lasheras; Joaquin Jordan; Norberto Aguirre

Book ID
111181240
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
451 KB
Volume
108
Category
Article
ISSN
0022-3042

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## Abstract Sildenafil, given shortly before 3,4‐methylenedioxymethamphetamine (MDMA), affords protection against 5‐hydroxytryptamine (5‐HT) depletions caused by this amphetamine derivative by an acute preconditioning‐like mechanism. Because acute and delayed preconditionings do not share the same