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Phospho-control of TGF-β superfamily signaling

✍ Scribed by Wrighton, Katharine H; Lin, Xia; Feng, Xin-Hua

Book ID
109846880
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
813 KB
Volume
19
Category
Article
ISSN
0007-0610

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Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different serine/threonine kinase receptors, i.e. type I and type II receptors. Upon ligand binding, type I receptors specifically activate intracellular Smad proteins. R‐Smads are direct substrates of type I receptors; Smad