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Phosphinic peptides as zinc metalloproteinase inhibitors

✍ Scribed by V. Dive; D. Georgiadis; M. Matziari; A. Makaritis; F. Beau; P. Cuniasse; A. Yiotakis

Publisher
Springer
Year
2004
Tongue
English
Weight
350 KB
Volume
61
Category
Article
ISSN
1420-682X

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## Abstract The __in vivo__ disposition and antitumor efficacy of a newly developed phosphinic matrix metalloproteinase inhibitor (RXP03) were examined. RXP03 potently inhibits MMP‐11, MMP‐8 and MMP‐13, but not MMP‐1 and MMP‐7. Twenty‐four hours after i.p. injection into mice, most of the RXP03 was