Phosphatidylserine plasma membrane asymmetry in vivo: a pancellular phenomenon which alters during apoptosis

A novel assay to measure loss of plasma

A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

✍ Manon van Engeland; Frans C. S. Ramaekers; Bert Schutte; Chris P. M. Reutelingsp 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 856 KB

Early during the process of apoptosis, cells lose their phospholipid membrane asymmetry and expose phosphatidylserine (PS) at the cell s h c e while maintaiaing their plasma membrane integrity intact. This process can be monitored for suspended cell types by using annexin V-FITC, which is a Ca\*+-de