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Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1

✍ Scribed by Aleksandr Kirov; Huda Al-Hashimi; Phil Solomon; Courtney Mazur; Philip E. Thorpe; Peter J. Sims; Francesca Tarantini; Thallapuranam K. Suresh Kumar; Igor Prudovsky

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
870 KB
Volume
113
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

The mechanisms of nonclassical export of signal peptide‐less proteins remain insufficiently understood. Here, we demonstrate that stress‐induced unconventional export of FGF1, a potent and ubiquitously expressed mitogenic and proangiogenic protein, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine (PS). In addition, we found that the differentiation of promonocytic cells results in massive FGF1 release, which also correlates with membrane blebbing and exposure of PS. These findings indicate that the externalization of acidic phospholipids could be used as a pharmacological target to regulate the availability of FGF1 in the organism. J. Cell. Biochem. 113: 956–966, 2012. © 2011 Wiley Periodicals, Inc.

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