Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells

Neuroprotective effect of guanosine agai

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition

✍ Simone Molz; Tharine Dal-Cim; Josiane Budni; M.D. Martín-de-Saavedra; Javier Ege 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 2 views

## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re