Phosphatidylinositol 3-kinase/AKT mediated phosphorylation of bad in human aortic endothelial cells exposed to sub saturating concentrations of anti-HLA class I antibodies confers resistance against antibody-complement mediated cell death

Pre-exposure to sub-saturating concentra

Pre-exposure to sub-saturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement-mediated lysis by regulating Bad through the phosphatidylinositol 3-kinase/Akt pathway

✍ Kishore Narayanan; Andrés Jaramillo; Donna L. Phelan; T. Mohanakumar 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 1 views

## Abstract Allografts transplanted across HLA‐sensitization results in an antibody‐mediated rejection known as hyperacute rejection. Depleting anti‐graft antibodies from the recipient by plasmapheresis prior to transplantation can prevent this rejection. We developed an __in vitro__ model using po